20 , 21 Much earlier, Selyes concept was born outside of the gastrointestinal tract, in the adrenal gland, and Selye conceptualized the general syndrome of adaptation (i.e., adrenal gland hypertrophy, thymolymphatic involution, and stomach stress ulcers) to achieve general homeostasis in the whole body while the derangement could explain the genesis of many stress-induced diseases
Given the rapid development of tools based on artificial intelligence and machine learning algorithms, it is essential to harness their potential for advanced analyses and integration of large-scale multi-omic datasets to identify novel early biomarkers of ASD, define molecular targets for new therapeutics, and develop libraries of new compounds with the potential to alleviate behavioral disturbances characteristic of individuals with ASD [137, 138]
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The Egyptians identified local foot pain, notably in the big toe, as a specific disease in 2640 BCE, before the word gout was ever used
